Sexual Intercourse and Vaginal Absorption of Progesterone

• Status: Not yet recruiting
• Trial end date: 2028-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this project is to compare the vaginal absorption of progesterone administered in the vaginal ovum by measuring progesteroneemia in 3 situations (or "sexual event"): abstinence, sex protected by condoms and unprotected sex.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Montpellier
• Treatments: Estradiol; Progesterone

Criteria

Inclusion Criteria:

• Couples, volunteers, on an AMP journey

• Having sexual intercourse with a low risk of transmission of sexually transmitted infection

• Free and informed consent to participate in the study

Inclusion criteria specific to women:

• aged 18 to 40 inclusive

Exclusion Criteria:

Exclusion criteria specific to women:

• Currently taking hormone therapy that may alter progesteroneemia

• Pathology that can modify progesteroneemia

• Body mass index greater than or equal to 32 kg / m2

• Contraindication to the use of hormone replacement therapy

• Known intolerance to vaginal progesterone

• Pregnant woman (βHCG assay positive) or breastfeeding

Exclusion criteria specific to men:

• Erectile or ejaculatory disorder

Exclusion criteria specific to couples:

• Person with poor oral and/or written French comprehension

• Person who for psychological, social, family or geographical reasons could not be followed regularly

• Vulnerable person (Article L1121-6 of the Public Health Code)

• Protected person or unable to give consent

• Person involvment in another clinical research

• Person not affiliated with a French social security scheme or beneficiary of such a scheme