Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid
Status:
Recruiting
Trial end date:
2022-09-30
Target enrollment:
Participant gender:
Summary
Three separate interventions will be undertaken with the primary outcome of improving pulse
wave velocity. Initially, age and BMI-matched men and post-menopausal women, all with type 2
diabetes, will be treated with allopurinol (20 men, 20 women) for 6 months, in order to
reduce serum uric acid (SUA) concentrations relative to placebo (10 men, 10 women). In a
second intervention, dietary fructose will be restricted for a period of 6 months in type 2
diabetes (T2D) subjects who will maintain a stable weight (20 men, 20 women). In a third
intervention, dietary fructose will be restricted for a period of 6 months in type 2 diabetes
(T2D) subjects who will achieve a caloric deficit and weight reduction (20 men, 20 women). At
the beginning and end of each of the studies, measures of arterial stiffness will be combined
with assessments of endothelial function (flow-mediated dilation and insulin stimulated leg
blood flow), measurements of systemic inflammation and oxidative stress.