Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

• Status: Not yet recruiting
• Trial end date: 2025-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Missouri-Columbia
• Treatments: Acetylcholine; Isoproterenol; Nitroprusside; Norepinephrine; Propranolol

Criteria

Inclusion Criteria:

• Healthy weight (BMI >18 and <25 kg/m2)

• Obese (BMI ≥30 kg/m2)

Exclusion Criteria:

• Pregnancy, breastfeeding

• Diagnosed sleep apnea or AHI >10 events/hr

• Current smoking/Nicotine use

• Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy

• Nerve/neurologic disease

• Cardiovascular, hepatic, renal, respiratory disease

• Blood pressure ≥140/90 mmHg

• Diabetes, Polycystic ovarian syndrome

• Communication barriers

• Prescription medications, Sensitivity to lidocaine