Sex Differences in Neurobehavioral Response to THC
Status:
NOT_YET_RECRUITING
Trial end date:
2027-12-31
Target enrollment:
Participant gender:
Summary
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
Phase:
PHASE2
Details
Lead Sponsor:
Medical University of South Carolina
Collaborators:
National Institute on Drug Abuse (NIDA) National Institutes of Health (NIH)