Sevoflurane's Effect on Mitral Valve Annular Velocity in Cardiac Surgery

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine sevoflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular velocity at three different sevoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE)in cardiac surgery patients.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Konkuk University Medical Center
• Treatments: Sevoflurane

Criteria

Inclusion Criteria:

• patients undergoing cardiac surgery

Exclusion Criteria:

• low ejection fraction < 50% in preoperative transthoracic echocardiography

• atrial fibrillation

• pacemaker

• pericardial and infiltrative myocardial disease

• mitral annular calcification, surgical rings, prosthetic mitral valves

• lateral left ventricular regional wall motion abnormality

• esophageal spasm,stricture, laceration, perforation, and diverticulum

• diaphragmatic hernia,

• history of extensive radiation to the mediastinum

• upper gastrointestinal bleeding