Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.
Status:
Completed
Trial end date:
2019-12-11
Target enrollment:
Participant gender:
Summary
Endothelial damage has been reported after ischemia-reperfusion events. This can be
characterized by measurements of glycocalyx and endothelial components that are released to
blood after the insult. Sevoflurane and inhaled anesthetic commonly used for surgery have
shown protective endothelial effects in animal and in-vitro models. Knee-ligament surgery
with the use of a femoral tourniquet generates a transient ischemia-reperfusion (IR) state
after the tourniquet is released. This research aims to compare the effect of sevoflurane and
propofol in the release of glycocalyx and endothelial biomarkers after IR in this surgical
scenario.