Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation
Status:
Unknown status
Trial end date:
2019-11-01
Target enrollment:
Participant gender:
Summary
Prospective, open-label, single-center, study to investigate the effect of sevoflurane
sedation compared to a propofol-controlled arm during COPD exacerbation requiring invasive
mechanical ventilation in ICU.
Primary outcome measure:
Evolution of airway resistance before and after sevoflurane in COPD patients,
Secondary outcomes measures:
Respiratory mechanics (Maximum pressure, PEEPi and PEEPtot, trapped volume), Gas exchange by
the help of blood gases, The heterogeneity of alveolar ventilation by electro-impedancemetry,
Evolution of pulmonary inflammation, Trophicity and contractility of the diaphragm,