Sevoflurane and Propofol Anesthesia on Postoperative Delirium
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Delirium is defined as an acute onset and fluctuating course of mental status change with
inattention and an altered level of consciousness. Delirium in the postoperative period can
be divided into emergence delirium and postoperative delirium, based on the time of onset
(Silverstein et al., 2007).Postanaesthesia delirium is a frequent and potentially serious
problem affecting the safety of patients and medical personnel. Clinical studies demonstrated
that postoperative delirium is associated with worse outcomes such as prolonged hospital
stay, postdischarge institutionalization, and increased mortality (Ely et al., 2004a;
Thomason et al., 2005; Robinson et al., 2009). Multiple factors may contribute to the
development of postoperative delirium, including patient's medical condition, administration
of anesthetics or analgesics and degree of operative stress (Yildizeli et al., 2005; Robinson
& Eiseman, 2008; Deiner & Silverstein, 2009). Sevoflurane anesthesia have been reported to be
associated with more emergence delirium in pediatric patients, when compared with propofol
anesthesia. It is not clear if propofol anesthesia will benefit the geriatric patients on
postoperative delirium, when compared with sevoflurane anesthesia. We hypothesize that
propofol anesthesia will reduce the rate of postoperative delirium by 50% when compared with
sevoflurane anesthesia.