Sevoflurane and Laryngeal Reflex Responses in Pediatric Patients
Status:
Terminated
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
To describe laryngeal and respiratory reflex responses after controlled laryngeal stimulation
in pediatric patients anesthetized with sevoflurane and to compare the evoked responses at
two levels of anesthesia. To determine whether laryngeal and respiratory reflex responses
after controlled laryngeal stimulation are completely suppressed in subjects when
anesthetized with a MACEI95 (EI = endotracheal intubation) sevoflurane Hypothesis: The
incidence of apnea with laryngospasm evoked by laryngeal stimulation will be reduced by 20%
(from 25% to 5%) when the end-tidal concentration of sevoflurane is increased from 2.5%
(MAC50) to 4.7% (MACEI95)