Sevoflurane Sedation on Intra Cranial Pressure in Traumatic Brain Injury Patients

• Status: Terminated
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Main purpose of the study is to evaluate the effect of sevoflurane on intra cranial pressure (ICP) after traumatic brain injury. Patients admitted for traumatic brain injury equipped with ICP measurement will be sedated with sevoflurane via the Anaconda device during 12 hours. Sedation will be controlled with BIS.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborator: Ministry of Health, France
• Treatments: Sevoflurane

Criteria

Inclusion Criteria:

• severe traumatic brain injury (glasgow < 8)

• age > 18

• no surgery scheduled

• sedation with midazolam and sufentanil

• ICP sensor

Exclusion Criteria:

• external ventricular derivation

• pregnancy

• antecedent of malign hyperthermia

• haemodynamic instability