Sevoflurane Sedation in Patients With Septic Shock
Status:
Not yet recruiting
Trial end date:
2024-11-01
Target enrollment:
Participant gender:
Summary
Recent in vivo studies from others as well as the investigators group demonstrated that
volatile anesthetics immunomodulate sepsis and improve outcome. Also, several clinical trials
have convincingly shown that application of a volatile anesthetic provides protection in
patients undergoing major surgery.
Patients with sepsis are intubated and ventilated and therefore need sedation. So far, most
ICU centers use intravenously applied sedatives in these patients. In the proposed study, we
will switch sedation from an intravenous to a volatile anesthetic for a short period of time
to explore if sepsis markers improve within the following 120 hours upon sevoflurane
conditioning.
Phase:
Phase 2
Details
Lead Sponsor:
University of Zurich
Collaborators:
Kantonsspital Münsterlingen Triemli Hospital Waid City Hospital, Zurich