Sevoflurane Induced Emergence Agitation

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Investigators evaluated the effect of intranasal ketamine or alfentanil addition to oral midazolam for prevention of emergence agitation.Seventy-eight, 1-8 year-old children, undergoing urological surgery with sevoflurane anesthesia was included in the study. All the children received oral midazolam 0.5 mg/kg 40 minutes before anesthesia induction then enrolled to one of the study groups, randomly. Ketamine group (Group MK; n=26) patients were given 2mg/kg intranasal ketamine whereas, alfentanil group (Group MA; n=25) were given 10microgram/kg intranasal alfentanil 8-10 min before the induction of anesthesia. Saline group (Group MS; n=27) received intranasal isotonic saline.Parental separation, mask acceptance were evaluated with a 4- point scale. Emergence agitation was evaluated with Pediatric Anesthesia Emergence Delirium score.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yeditepe University Hospital
• Treatments: Alfentanil; Ketamine; Midazolam; Sevoflurane

Criteria

Inclusion Criteria:

• 1- 8 years

• American Society of Anesthesiologist (ASA) I-II,

• Patients undergoing procedures below the umbilicus

Exclusion Criteria:

• cardiac diseases

• pulmonary diseases

• hepatic diseases

• renal diseases

• psychological or emotional disorders