Sevelamer and Secondary Hyperparathyroidism in Chronic Kidney Disease
Status:
Completed
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
The hypothesis underlying this study is that phosphate interferes with PTH-mediated calcium
reabsorption in the distal nephron and thereby necessitates supranormal [PTH]to maintain
normocalcemia in chronic kidney disease. This study will examine the hypothesis with measures
of phosphate homeostasis and calcium reabsorption. A double-blind trial of the intestinal
phosphate binder sevelamer carbonate will be employed to examine whether reductions in
phosphate influx alter distal nephron phosphate concentration and the [PTH] required for
calcium reabsorption in the expected manner.