In the window of implantation, progesterone plays an important role. Sufficient serum
progesterone is basic for ongoing pregnancy. Vaginal progesterone is more and more widely
used in ART. As it has no hepatic first pass effect. What is the optimal serum level for
pregnancy when use vaginal progesterone is not known yet? Hormone replacement therapy- FET is
the optimal strategy to explore this question. There are some retrospective studies showed
that the serum progesterone level on embryo transfer day (D3 or D5) or pregnancy test day
(D14) lower than 10-11ng/ml is significantly associated with ongoing pregnancy rate in
HRT-FET cycles. This prospective study is designed to compare the ongoing pregnancy rate
between different serum progesterone levels on D3 and to explore the intervention of
additional progesterone supplement since D3 is helpful in HRT-FET cycles.
Phase:
N/A
Details
Lead Sponsor:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University