Serum Levels of Doxycycline at the Time of Abortion With Two Dosing Regimens
Status:
Completed
Trial end date:
2006-05-01
Target enrollment:
Participant gender:
Summary
This is a randomized double-blind, controlled trial comparing two regimens of pre-abortion
doxycycline. The aims of the study are to determine the serum levels of doxycycline when
administered pre-operatively 4 hours or approximately 18 hours before a dilation and
evacuation (D & E) abortion. The hypotheses being tested are that subjects who receive
doxycycline with food the night before an abortion will have adequate serum levels, but less
nausea and vomiting compared to women who take the doxycycline on an empty stomach on the
morning of the abortion. Subjects will either take 200mg doxycycline on the night before and
2 caps placebo with a sip of water on the morning of surgery or 2 caps placebo the night
before and 200mg doxycycline on the morning of surgery with a sip of water. All capsules will
look identical. Diaries, questionnaires and a 10cc sample of blood for doxycycline levels
will be collected from the subjects at the time of surgery.