Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids

• Status: Unknown status
• Trial end date: 2018-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Free fatty acid index will be measured in patients before and 1 month after high dose prednisone.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Prednisone

Criteria

Inclusion Criteria:

• Each participant must be at least 18 years of age.

• Each participant must give a written informed consent for participation in the study.

• Each participant must be drug naïve with respect to previous glucocorticoid treatment (history of less than 2-week treatment at any time is authorized, but with no recent glucocorticoid therapy over 3 months before study entry).

Exclusion Criteria:

• Obese subjects, defined as BMI > 35 or underweight subjects, defined as BMI < 18.5

• A history of eating disorder

• Diabetes mellitus

• A history of Cushing's syndrome, subclinical hypercortisolism, hypoadrenalism, or congenital adrenal hyperplasia

• Abnormal thyroid function test : history of hyperthyroidism or hypothyroidism

• Active cancer

• Uncontrolled hypertension >160/95

• Hypercholesterolemia, defined as LDL > 190

• Hypertriglyceridemia, defined as TG > 250

• Acute or Chronic renal failure (GFR < 45) or nephrotic syndrome

• Acute or chronic hepatitis or cirrhosis