Serum Concentration of Tranexamic Acid After Topical Administration in Massive Weight Loss Skin Reducing Surgery
Status:
Completed
Trial end date:
2018-02-28
Target enrollment:
Participant gender:
Summary
Tranexamic acid is a drug that prevents clotted blood from dissolving and hence reduces
bleeding. It is routinely given intravenously in many surgical situations where there is a
risk of major bleeding. Concerns regarding possible adverse effects from intravenous use
prevents a more widespread use, even in smaller surgeries. Topical application - using the
drug directly on the wound surface- may give a higher concentration at the site of bleeding
but a lower concentration in the rest of the body, and hence a lower risk of adverse effects.
Here it will be investigated to what extent a defined dose of the drug is absorbed
systemically - into the blood stream - when it is applied topically. This will then be
compared to the concentration in the blood stream when administered intravenously. Blood
samples will be obtained at defined time intervals after administration from patients
receiving topical and patients receiving intravenous administration of the same single dose
of tranexamic acid. Will less of the drug enter the blood stream if it is applied directly to
the wound?