Serum Bupivacaine Concentration Levels After Injection of Liposomal Bupivacaine Into the Knee

• Status: Completed
• Trial end date: 2016-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Serum levels of bupivacaine over time after peri-articular injection of a mixture of liposomal bupivacaine and plain bupivacaine during total knee arthroplasty.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Utah
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• Adults of at least 18 years of age having a primary, unilateral total knee arthroplasty with a surgical plan to have an intra-articular injection of a mixture of 266 mg of Exparel, 125 mg of bupivacaine, 1:300,000 epinephrine, and 0.9% saline to make a total volume of 100 ml.

Exclusion Criteria:

• Known hepatic dysfunction or renal insufficiency (creatinine > 1.5 mg/dL);

• allergy to the study medications;

• pregnancy;

• incarceration;

• inability to communicate with the investigators;

• morbid obesity (body mass index > 40 kg/m2).