Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism
Status:
Unknown status
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
Clustering of various metabolic parameters including abdominal obesity, hyperglycaemia, low
high-density lipoprotein cholesterol, elevated triglycerides and hypertension have been used
worldwide as metabolic syndrome to predict cardiometabolic risk. Thyroid dysfunction impacts
on various levels of these components.
Recent evidence from HepG2 cells indicates that betatrophin, also known as
TD26/RIFL/lipasin/ANGPTL8/C19orf80, a secreted protein that regulates glucose, lipid
metabolism, and energy homeostasis, is induced by T3. However, the role of betatrophin in
hyperthyroid patients is unknown.
The objective was to study serum betatrophin levels in hyperthyroid patients and the
association of serum betatrophin levels with hyperthyroidism.