Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism

• Status: Unknown status
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Clustering of various metabolic parameters including abdominal obesity, hyperglycaemia, low high-density lipoprotein cholesterol, elevated triglycerides and hypertension have been used worldwide as metabolic syndrome to predict cardiometabolic risk. Thyroid dysfunction impacts on various levels of these components.

Recent evidence from HepG2 cells indicates that betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, a secreted protein that regulates glucose, lipid metabolism, and energy homeostasis, is induced by T3. However, the role of betatrophin in hyperthyroid patients is unknown.

The objective was to study serum betatrophin levels in hyperthyroid patients and the association of serum betatrophin levels with hyperthyroidism.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hu Hao
• Treatments: Methimazole; Propranolol; Propylthiouracil

Criteria

Inclusion Criteria:

• Clinical diagnosis of hyperthyroidism

• Must be drug-naive before recruitment

Exclusion Criteria:

• diabetes

• hypertension

• cancer

• pregnancy

• lactation

• subacute thyroiditis

• postpartum thyroiditis

• abnormal liver function

• abnormal kidney function

• infectious diseases