Sertraline Effect in Uremic Pruritis

• Status: Not yet recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to assess the effect of sertraline on uremic pruritis in patients undergoing regular haemodialysis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Alexandria University
• Treatments: Sertraline

Criteria

Inclusion Criteria:

1. ≥1 month of maintenance haemodialysis, 3 times per week for 4 hours.

2. Adult patients with ages between 18-80 years.

Exclusion Criteria:

1. Primary skin diseases (eczema, psoriasis, allergic dermatitis or drug rash).

2. Peripheral neuropathy, thyroid disease, leukemia, lymphoma, liver disease, Systemic lupus erythematosus or pregnancy.

3. Patients who consumed emollients cream, antihistamine, opioid antagonist, immunosuppressants, cholestyramine, corticosteroids or UVB phototherapy 1 month before study.

4. calcium X phosphorus (Ca X P) >55.0 mg/dl, P >5.5 mg/dl, parathyroid hormone (PTH) >450 pg/ml.

5. Selective serotonin reuptake inhibitors intolerance.