Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures

• Status: Not yet recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture. The main questions it aims to answer are:

• What are the obstacles to enrolling patients and prescribing anti-depressants among older adults?

• Is it possible to start prescribing SNRI medication upon discharge?

• What is the prevalence of depressive symptoms amongst patients with different types of injuries and weightbearing status?

• What is a transition of care plan for patients who have geriatric depression and require further care?

Participants will:

• Undergo screening using the Geriatric Depression Scale

• Start on Duloxetine 30mg daily at time of discharge

• Report medication compliance and complete re-screening monthly

• Complete patient reported outcome measures and 3 months, 6 months, and 1 year

• Receive a referral to behavioral health, primary care, or psychiatrist for evaluation if they screen positive at any timepoint

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wake Forest University Health Sciences
• Treatments: Duloxetine Hydrochloride

Criteria

Inclusion Criteria:

• Geriatric (greater than or equal to 65 years old)

• Lower extremity fragility fractures managed operatively

Exclusion Criteria:

• Polytrauma

• Pathological fractures

• Patients on hospice

• Patients with previously diagnosed psychiatric disorders

• Patients with previously diagnosed dementia

• Patients already taking Selective serotonin reuptake inhibitors (SSRI)s and Serotonin- norepinephrine reuptake inhibitors (SNRI)s

• Patients already taking mood stabilizing medication

• Unable to provide informed consent (no use of a legal authorized representative)

• Patients with pre-existing life limiting diagnoses (cancer, etc.)