Serotonin and the Upper Airway in Obstructive Sleep Apnea
Status:
Completed
Trial end date:
2003-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if a certain medication, alone or combined with
another medication, will increase muscle activity in the upper airway in people who do and
people who do not have sleep apnea. The medications being studied are paroxetine, a commonly
used antidepressant, and 5 hydroxy-tryptophan (5HTP), which also can be used as a dietary
supplement without a prescription. Because the effects of paroxetine in previous studies were
not very large, we will also study it combined with 5HTP to see if the effect on the upper
airway muscles is greater.
Phase:
Phase 4
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development