Sequential Treatment of Psoriasis With Integrated Traditional Chinese and Western Medicine

• Status: Not yet recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to explore intervention time of Chinese medicine and specification of a sequential treatment plan for severe psoriasis with Chinese and Western medicine.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Yueyang Integrated Medicine Hospital
• Collaborators: Chinese Medicine Hospital Affiliated to Southwest Medical University; Jiangsu Province Hospital of Traditional Chinese Medicine; Shanghai Dermatology Hospital; The Second People's Hospital Affiliated to Fujian University of TCM; Wuhan No.1 Hospital

Criteria

Inclusion Criteria:

1. Plaque psoriasis, the course of disease is not limited.

2. Skin lesions involving ≤ 15% BSA (the lesions are mainly located in the trunk and / or limbs, palm / sole, face / scalp, vulva area is not included).

3. 18 to 65 years old, male or female patient.

4. Informed consent must be obtained.

Exclusion Criteria:

1. other active skin diseases which may affect the condition assessment are present.

2. Patients who received systematic treatment of research drugs, biological agents and immunosuppressive agents within 2 months.

3. Patients who received treatment with topical glucocorticoids, phototherapy, etc. within 2 weeks.

4. Those with severe, uncontrollable local or systemic acute or chronic infections.

5. patients with severe systemic diseases; or clinical test indicators in one of the following cases: alanine transferase or glutamate transferase increased by >1.5 times the upper limit of normal; serum creatinine increased by >1.5 times the upper limit of normal Any of the main blood routine indicators (white blood cell count, red blood cell count, hemoglobin amount, platelet count) below the lower limit of normal; or other laboratory abnormalities judged by the investigator are not suitable for participation in this trial.

6. Patients with a history of malignant tumors and patients with primary or secondary immunodeficiency and hypersensitivity.

7. Patients underwent major surgery within 8 weeks or will require such surgery during the study period.

8. Patients who are pregnant or in lactation.

9. Those have a history of alcohol abuse, drug abuse or drug abuse.

10. Patients with a history of serious mental illness or family history.

11. Patients with a family history of cancer.

12. Other reasons that the investigator considered inappropriate to participate in the study.