Sequential Therapy of TCM Herbs to Improve the Success Rate of IVF-ET in Diminished Ovarian Reserve Patients
Status:
Recruiting
Trial end date:
2022-12-30
Target enrollment:
Participant gender:
Summary
In the early stage, our team found that traditional Chinese medicine (TCM) intervention aimed
at Nourishing kidney and regulating blood circulation in vitro fertilization and embryo
transfer(IVF-ET) can improve the clinical pregnancy rate. In order to further study the role
of TCM in improving the pregnancy outcome of IVF-ET in infertility due to decreased ovarian
reserve (DOR). A randomized controlled clinical trial was used in this study. 200 infertile
patients with DOR were randomly divided into two groups. The control group was treated with
conventional modern medicine, and the treatment group was treated with traditional Chinese
herbs on the basis of conventional modern medicine.
The intervention started from the 5th day of the first menstrual cycles after enrollment and
lasted for three months before IVF-ET. After the transplantation, the TCM treatment continues
for 14 days. The number of oocytes, antral follicles, anti-Mullerian hormone(AMH), serum
follicle-stimulating hormone(FSH), and clinical pregnancy rate will be observed to evaluate
the effect of traditional Chinese medicine on the improvement of ovarian function, pregnancy
outcome, and fertility of DOR patients.