Sequential Neoadjuvant Chemotherapy in Soft Tissue Sarcoma
Status:
Recruiting
Trial end date:
2034-09-01
Target enrollment:
Participant gender:
Summary
Nearly half of patients with high-grade, localized soft tissue sarcoma (STS) of extremities
and trunk wall develop disease recurrence after local therapy. Adjuvant chemotherapy with
ifosfamide and doxorubicin may improve long-term disease-free survival, but the benefit of
adjuvant treatment is limited and predictive factors for treatment response are lacking. The
aim of this study is to explore sequential treatment with ifosfamide and doxorubicin in a
neoadjuvant setting and to investigate biomarkers predictive of treatment response.