Overview

Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Status:
RECRUITING
Trial end date:
2030-02-28
Target enrollment:
Participant gender:
Summary
This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
Phase:
PHASE4
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborator:
Patient-Centered Outcomes Research Institute
Treatments:
Aripiprazole
cariprazine
Escitalopram
Lurasidone Hydrochloride
Quetiapine Fumarate