Sequential HIV Therapy in Treatment Resistant HIV-1 Infected Patients

• Status: Terminated
• Trial end date: 2007-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This is an open label, crossover pilot study to explore the safety and efficacy of a rapid cycling regimen of antiretroviral combination therapy in HIV-1 infected patients with virus harboring genotypic resistance to at least three classes of antiretroviral therapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Collaborator: Dutch AIDS Fund
• Treatments: Anti-Retroviral Agents

Criteria

Inclusion Criteria:

• HIV-1 infected patients

• At least 18 years of age

• Males or non-pregnant, non-lactating females

• Documented virological treatment failure on at least 3 classes of antiretroviral drugs

• No adequate antiretroviral therapy possible with currently available antiretroviral agents

• Virological treatment failure is defined as plasma HIV-1 RNA levels > 5000 while taking at least three different antiretroviral drugs