Septic Encephalopathy and Late Cognitive Dysfunction
Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Delirium and long-term cognitive dysfunction are important problems in intensive care
patients. Patients with sepsis are at a high risk of developing delirium (septic
encephalopathy), which may be an important risk factor for the development of long-term
cognitive dysfunction.
Working hypotheses: 1. Septic encephalopathy and cognitive dysfunction are caused by an
unspecific reaction of the brain to an intense inflammatory stimulus. 2. It is possible to
therapeutically influence the inflammatory response and its effects on the brain.