Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline
Status:
Not yet recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic
Voluntary Hyperventilation (EVH) and Hypertonic Saline (HS) in individuals with cough variant
asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and
compare these responses to a control group of healthy individuals without asthma or chronic
cough.
We hypothesize:
1. EVH and HS cause dyspnea, cough, small airway obstruction with resultant dynamic
hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not
healthy controls.
2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and HS) are
comparable within groups (CVA, COUGH and healthy controls).