Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH)
Status:
Unknown status
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Headache following a lumbar puncture (post-lumbar-puncture headache,PLPH)is a common and
often debilitating syndrome, which was reported to occur in about 40% patients who received
lumbar puncture. Now there lacks of effective approaches in the prophylaxis of PLPH, although
some physicians consider bed rest for at least 6 hours to be a useful methods (Some recent
meta-analysis found no benefit of bed rest for any hours in the prevention of PLPH). Studies
have found that P substances and its receptor (Neurokinin-1 receptor, NK-1R)have played an
important role in the pathogenesis of PLPH. Thus, we hypothesize that use of NK-1R inhibitor
(aprepitant) 1 hour before lumbar puncture may decrease the incidence of PLPH and lower the
severity of PLPH.