Self-Injury: Diagnosis and Treatment

• Status: Unknown status
• Trial end date: 2002-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Self-injurious behavior is behavior in which a person hurts or harms himself. This behavior sometimes occurs in people with mental retardation or autism. This study will evaluate self-injurious behavior in people with mental retardation or autism and will test the effectiveness of new treatments.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Treatments: Naltrexone

Criteria

Inclusion Criteria

• Self-injurious behavior for at least 3 months prior to study entry

• Normal cardiac, liver, and kidney function as determined by a physician

Exclusion Criteria

• Only presenting problems are pica, aggression, property destruction, hyperkinesis, screaming, or eating disorders

• Lesch-Nyhan syndrome

• Peripheral neuropathy

• Self-injury that presents immediate imminent risk such as loss of sight or hearing or other potentially life threatening behavior

• Serious chronic health impairments associated with specific syndromes (e.g., Cornelia de Lange, Prader Willi Syndrome)

• Self-injury unresponsive to prior conventional behavioral or pharmacological interventions (e.g., less than 50% reduction in overall self-injury for 3 months)

• Major depressive disorder or schizophrenia