Selective Digestive Decontamination in Carriers of Carbapenem-resistant Klebsiella Pneumoniae

• Status: Completed
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

There is an urgent need to control our current national outbreak of carbapenem-resistant Klebsiella pneumoniae (CRKP). The purpose of this study is to eradicate CRKP gastrointestinal carriage using selective digestive decontamination (SDD); with buccal and oral gentamicin and polymyxin E administration. This will reduce infections and hopefully mortality caused by CRKP.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Soroka University Medical Center
• Treatments: Colistin; Gentamicins; Pharmaceutical Solutions; Polymyxins

Criteria

Inclusion Criteria:

• Hospitalized men and women with a positive rectal swab for CRKP

• Age 18 years or older

Exclusion Criteria:

• Age less than 18 years

• Pregnant women, lactating women

• A known allergy to the study drugs