Seizure Prophylaxis in Aneurysm Repair

• Status: Terminated
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Seizures are a potential complication of surgical repair of intracranial aneurysms. In order to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during the intra-operative and post-operative period, however, such practice is not supported by clinical data. Retrospective review found the incidence of postoperative seizures was higher in those who received anti-epileptics versus those who did not. The goal is to examine the utility of levetiracetam (Keppra) for seizure prophylaxis in patients undergoing surgical repair of unruptured intracranial aneurysms.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indiana University
• Treatments: Etiracetam; Levetiracetam

Criteria

Inclusion Criteria:

1. Adult (≥18 years)

2. Presence of intracranial aneurysm (without rupture)

3. Treating surgeon has recommended surgical repair of the aneurysm.

Exclusion Criteria:

1. History of seizures within last 10 years

2. History of epilepsy

3. History of prior stroke

4. Currently prescribed medication with anti-epileptic activity (keppra,dilantin, tegretol, lamictal, topamax, etc.)

5. Brain tumor

6. Pregnant or nursing woman

7. Known levetiracetam allergy