Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma
Status:
Completed
Trial end date:
2017-03-21
Target enrollment:
Participant gender:
Summary
Sedation in the operating room, the Post Anesthesia Care Unit and the Intensive Care Unit is
common and often necessary for patients with intracranial brain tumor. Repeated neurological
function assessments is needed in those locations, especially in patients with tumors in or
near eloquent regions, this is to monitor their neurologic performance to determine if there
are alterations that require treatment. Some slowly infiltrative low-grade gliomas near
eloquent regions do not show any detectable neurologic deficits, perhaps from reorganization,
but with sedation by some sedatives such as benzodiazepine midazolam and anesthetic hypnotic
propofol, the disease may seem much worse resulting in inappropriately aggressive treatment.
This may be especially problematic in patients undergoing awake craniotomy for tumors in
eloquent regions.
This is a single-center perspective study. Patients will be mildly sedated to keep them
responsive and cooperative. Motor and sensory function will be evaluated before and after
mild sedation. Specific benzodiazepine antagonist will be used if sedated by midazolam.
The purpose of this study is to observe if commonly used benzodiazepine midazolam exacerbates
or unmasks motor and sensory function in patients with intracranial eloquent area gliomas.
Hypothesis:
mild sedation can unmasks or exacerbate motor and sensory deficits in patients with eloquent
area glioma but not in non-neurosurgical patients/healthy volunteers. If the neurologic
deficits induced by benzodiazepine agonist, then can be reversed by flumazenil.
Phase:
N/A
Details
Lead Sponsor:
Beijing Tiantan Hospital
Treatments:
Dexmedetomidine Hypnotics and Sedatives Midazolam Propofol