Sedative-Anxiolytic Effects on Simulated Driving Performance

• Status: Completed
• Trial end date: 2018-10-25
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the effect of anxiety drugs taken at night on the ability to drive a car the next day. Participants will receive alprazolam, placebo, or zolpidem at night before bed or in the morning before using a driving simulator to assess impairment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Marion Coe
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Alprazolam; Zolpidem

Criteria

Inclusion Criteria:

• valid driver's license

• english-speaking and literate

Exclusion Criteria:

• using daily medication for chronic condition

• acute narrow angle glaucoma

• previous adverse experience with study drugs

• experiences motion sickness in response to driving simulator

• BMI > 30

• women who are pregnant, lactating, or planning on becoming pregnant

• regular use of tobacco products

• current substance use disorder

• clinically significant ECG

• current ongoing psychiatric disorder