Sedation of Mechanically Ventilated Critically Ill Patients: Midazolam Versus Dexmedetomidine
Status:
Unknown status
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
The aim of this prospective randomized study is to compare the safety and efficacy of two
strategies for sedation of critically ill patients submitted to mechanical ventilation:
continuous intravenous infusion of dexmedetomidine versus intravenous bolus of midazolam. The
two groups will be compared as to the incidence of of delirium, evaluated with the Confusion
Assessment Method for ICU (CAM-ICU) and the percentage of time within the target sedation
using the Richmond Agitation-Sedation Scale (RAAS).Eligible patients will be 18 years or
older intubated and mechanically ventilated for less than 48 hours prior to start of study
drug and anticipated ventilation duration of at least 48 hours. Calculated sample size is 146
patients (73 patients in each group)