Propofol (Propofol Kabi, Registration number from the State Register of Medicines - 000875)
is a widely used intravenous anesthetic. It is well known about different effects of propofol
infusion, including euphoria, psycholalia, disinhibition, talkativeness, satisfaction etc.
However, the basic mechanisms of such effects remain unknown. We suppose that propofol
sedation with various levels of sedation (from light to deep) leads to neuromediators
changes. We examine dopamine, noradrenaline, acetylcholine, GABA and serotonin in peripheral
venous blood before, during and after propofol sedation. Therefore, we suppose drugs for
sedation, in particular, propofol will affect neuromediators concentration.
Phase:
N/A
Details
Lead Sponsor:
I.M. Sechenov First Moscow State Medical University