Overview

Sedation Versus General Anesthesia for Endovascular Therapy in Acute Stroke - Impact on Neurological Outcome

Status:
Completed
Trial end date:
2016-09-30
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to evaluate whether general anesthesia or sedation technique is preferable during embolectomy for stroke, measured in terms of three months neurological impairment. In addition we study if there is any difference between the methods regarding complication frequency.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Sahlgrenska University Hospital, Sweden
Treatments:
Anesthetics
Remifentanil
Sevoflurane
Criteria
Inclusion Criteria:Patients with acute stroke considered for thrombectomy and meeting the
following inclusion criteria included:

1. the patient is ≥ 18 years

2. the patient has a CT angio verified embolization * and / or a NIHSS scores ** ≥ 10 (R)
or 14 (L) depending on the side engagement

3. embolectomy (= groin puncture) started <8 hours after symptom onset

- Embolus in one of the following arteries: internal carotid artery, anterior
cerebral (A1 segment), cerebri media (M1 segment) and proximal cerebri media
branches (M2 segment).

- NIHSS (National Institutes of Health Stroke Scale). Patients with embolus in
left hemisphere circulation require ≥ 14 points, while patients with embolus
in the right hemisphere circulation require ≥ 10 points. This is because
occlusion on the right side does not usually cause aphasia, a symptom that
usually leads to higher total score of NIHSS.

Exclusion Criteria:

1. the patient must receive general anesthesia, for medical reasons, according to the
responsible anesthesiologist

2. the patient cannot receive general anesthesia, for medical reasons, according to the
responsible anesthesiologist

3. the patient has an embolization of posterior brain vessels

4. CT-confirmed intracerebral hemorrhage

5. spontaneous recanalization or spontaneous neurological improvement

6. any other reason that does not allow embolectomy (co-morbidities)

7. premorbid MRS ≥ 4