Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients
Status:
Unknown status
Trial end date:
2019-01-31
Target enrollment:
Participant gender:
Summary
To investigate the effects of different sedation protocols on skeletal muscle metabolism in
mechanical ventilated patients in ICU. Mechanical ventilated patients who are anticipated to
stay in ICU for more than 5 days are enrolled and randomly assigned to the following three
groups, interventional group(dexmedetomidine), control group(midazolam) and no sedation
group. Serum, CT scan of intercostal muscles, ultrasound evaluation of quadriceps femoris are
obtained.