Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients

• Status: Unknown status
• Trial end date: 2019-01-31
• Target enrollment: 0
• Participant gender: All

Summary

To investigate the effects of different sedation protocols on skeletal muscle metabolism in mechanical ventilated patients in ICU. Mechanical ventilated patients who are anticipated to stay in ICU for more than 5 days are enrolled and randomly assigned to the following three groups, interventional group(dexmedetomidine), control group(midazolam) and no sedation group. Serum, CT scan of intercostal muscles, ultrasound evaluation of quadriceps femoris are obtained.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese Medical Association
• Treatments: Dexmedetomidine; Midazolam

Criteria

Inclusion Criteria:

• mechanical ventilated for more than 48h

• 18-80 years

• stay in ICU for more than 5 days

Exclusion Criteria

• already participated in other clinical trials

• pregnancy or lactation

• lower limb amputation

• primary neuro-muscular disease

• disseminated tumor or accepted special therapy

• alcohol abuse

• severe liver dysfunction(Child-Push C)

• unstable angina/acute myocardial infarction

• heart rates<50bpm

• all kinds dialysis

• severe burn

• epidural anesthesia

• severe neurological disease（acute stroke, uncontrollable epilepsy, severe dementia, etc）