Sedation MRI - Propofol Versus Propofol-Ketamin in Children
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
Children < 10 years of age often need deep sedation or anaesthesia to allow elective
diagnostic magnetic resonance imaging; standard routine protocols are
1. propofol induction without other sedative (Propofol much as needed) or hypnotic drugs
and propofol infusion 10 mg/kg h
2. propofol induction with ketamine 1 mg /kg (little repetitive Propofol doses as needed)
and propofol infusion 5 mg / kg h
both protocols are compared with regard to clinical outcome and, in cases with cerebral MRI,
cerebral perfusion/blood flow.
Hypothesis:
1. reduces recovery time compared to propofol mono sedation
2. combination of ketamine-propofol increases incidence of Postoperative nausea and
vomiting (PONV) compared to propofol mono sedation
3. combination of ketamine-propofol increases global cerebral blood flow and changes
regional distribution of cerebral perfusion compared to propofol mono sedation