Secretin Activates Human Brown Fat and Induces Satiation.
Status:
Completed
Trial end date:
2019-11-30
Target enrollment:
Participant gender:
Summary
15 healthy males will be studied with PET/CT, using FDG to investigate glucose metabolism,
and radiowater to investigate perfusion. One scan will be performed in controlled cold
exposure, to see whether subjects have cold activated brown adipose tissue. Two scans will be
performed in room temperature conditions, where all subjects are blinded and randomised to
receive placebo and secretin hydrochloride. PET/CT scans will be analysed blinded.
20 healthy males will also be studied with fMRI, in order to investigate brain activity
responses to appetizing versus bland foods. This study will be conduced on the same patients
as the PET/CT study, but additional subjects with same inclusion and exclusion criteria will
be recruited. Two fMRI scans will be performed in room temperature conditions, where all
subjects are blinded and randomised to receive placebo and secretin hydrochloride. fMRI scans
will be analysed blinded.