Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)
Status:
Completed
Trial end date:
2020-06-30
Target enrollment:
Participant gender:
Summary
A double-blind, individual randomised trial will be undertaken in 6000 children under the age
of five years living in areas of Burkina Faso or Mali where the transmission of malaria is
intense and highly seasonal to determine whether the malaria vaccine RTS,S/AS01 is (a) as
effective as SMC with SP + AQ in preventing clinical malaria (b) provides additional, useful
protection when given together with SMC. The primary trial end-point will be the incidence of
clinical episodes of malaria detected by passive case detection.
Phase:
Phase 3
Details
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborators:
Institut de Recherche en Sciences de la Sante, Burkina Faso Malaria Research and Training Center, Bamako, Mali