Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
This study is designed to assess the impact of new approaches to therapy for paracetamol
poisoning. Standard therapy is currently acetylcysteine by intravenous infusion over 20.25h.
This regimen is given to those deemed "at risk" using standard criteria (British National
Formulary 200920). It has 3 major problems, adverse events (nausea and vomiting and
anaphylactoid reactions), therapy duration and complexity of administration.
This study is primarily designed to test the efficacy of prophylactic anti-emetic therapy.
It will also provide sufficient experience and data from a modified shortened IV
acetylcysteine regimen to adequately design and power a study of the modified regimen as a
new treatment for this common poison. Such an approach has a major potential to reduce
patient adverse events from acetylcysteine therapy and shorten duration of hospital stay.
Phase:
Phase 4
Details
Lead Sponsor:
University of Edinburgh
Collaborators:
Chief Scientist Office of the Scottish Government NHS Lothian