School-Based Treatment With ACT to Reduce Transmission
Status:
Completed
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
We propose to evaluate the community-level impact of intermittent preventive treatment (IPT)
for malaria in schoolchildren on clinical outcomes and malaria transmission, using a
cluster-randomised design in Jinja, Uganda. Dihydroartemisinin-piperaquine (DP) will be
administered to schoolchildren monthly for up to six rounds of treatment during one school
year. Outcomes will be measured using surveys of communities, schoolchildren, and mosquito
vectors. Our proposal also includes health service research to evaluate the potential
feasibility of taking the programme to scale, which will guide future research and
implementation of the intervention, and help shape policies in Uganda and elsewhere in
Africa.
Phase:
Phase 4
Details
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborators:
Infectious Diseases Research Collaboration, Uganda University of California, San Francisco University of Durham