Scalp Infiltration With Diprospan Plus Ropivacaine for Postoperative Pain After Craniotomy in Adults
Status:
Completed
Trial end date:
2021-02-15
Target enrollment:
Participant gender:
Summary
Pain is common for the first 2 days after major craniotomy. A majority of patients would
suffer from moderate-to-severe postoperative pain after undergoing craniotomy. Inadequate
analgesia induced sympathetically mediated hypertension may lead to an increased risk for
post-operative complications, such as arterial hypertension, intracranial hemorrhage,
prolonged hospital stay, and mortality. Adequate pain control is essential for patients'
prognosis and their postoperative life quality. Pain after craniotomy derives from the scalp
and pericranial muscles. Local anesthetics administered around the incision have been
performed clinically. However, some studies revealed that the analgesic effect of local
anesthetics was not unsatisfactory due to its short pain relief duration. Pain is common for
the first 2 days after major elective intracranial surgery, and the relatively short
analgesic time of scalp infiltration does not seem to meet the requirements of craniotomy.
Steroid such as diprospan as an adjuvant to local anesthetics intra-articular injected
locally ameliorated pain intensity in knee osteoarthritis or in total knee arthroplasty.
However, there has not been reported about local application of diprospan on scalp
infiltration. Thus, the investigators suppose that pre-emptive scalp infiltration with
steroid (diprospan) plus local anesthetic (ropivacaine) could relieve postoperative pain
after craniotomy in adults.
Phase:
Phase 4
Details
Lead Sponsor:
Beijing Tiantan Hospital
Treatments:
Betamethasone Betamethasone dipropionate, betamethasone sodium phosphate drug combination Ropivacaine