Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock

• Status: Completed
• Trial end date: 2019-02-09
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether an aggressive strategy of severe sepsis patients since pre hospital care, including early antibiotics administration, hemodynamic optimization, and opotherapy when indicated, could reduce mortality

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Anti-Bacterial Agents; Ceftriaxone; Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Norepinephrine; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam

Criteria

Inclusion Criteria:

All patients fulfilling the following criteria:

• Age ≥ 18 years

• Patient with suspected severe infection defined by the existence of a suspected infection AND

• Hypotension before vascular fluid loading AND/OR

• Lactataemia greater than 4 mmol/l AND/OR

• Glasgow scale lower than 13 AND/OR

• Mottling score greater than 2

• Patient with a septic shock

Exclusion Criteria:

• Age <18 years or Unable

• Pregnant

• Severe concomitant pathology requiring urgent care(i.e.epilepsy)

• Status "not to be reanimated" life expectancy less than 6 months with no indication of reanimation support ( prior decision on care limitation).

• Fulminans purpura

• True allergy to beta-lactam defined by an angioedema or by an anaphylactic shock during a prior exposure to beta-lactam.

• Patient who have already received hemodynamic optimization or antibiotic treatment before the MICU's (Mobile Intensive Care Unit) care.