Overview

Salvage: Postconditioning With Adenosine for STEMI

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
Investigate the effect of selective intracoronary administration of adenosine on myocardial salvage and microvascular integrity in the setting of acute myocardial infarction.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University Hospital, Gasthuisberg
Treatments:
Adenosine
Criteria
Inclusion Criteria:

- Myocardial infarction of less than 12 hours duration with symptoms lasting at least 20
minutes.

- ECG-criteria: ST-segment elevation of > 0.1 mV in 2 or more limb leads or > 0.2 mV in
2 or more contiguous precordial leads or presumed new left bundle branch block.

- Written informed consent prior to inclusion in the study. If this is not possible,
verbal informed consent from the patient or written assent of a legally acceptable
representative should be obtained, to be followed by written informed consent by the
patient at the earliest subsequent opportunity.

- Adequate vascular access seems possible (femoral pulsation palpable).

Exclusion Criteria:

- Contra-indication to heparin, LMWH, clopidogrel.

- Anticipated difficulty with vascular access.

- Cardiogenic shock.

- Inability to give informed consent (or assent).

- High grade atrioventricular block; severe asthma; treatment with theophylline,
glibenclamide (Diamicron) or dipyridamole.

- Prior CABG.

- Participation in an investigational drug or device study within the past 30 days.