Salsalate Therapy to Reduce Insulin Resistance and Cardiovascular Risk
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
The hypothesis is that salsalate therapy may be an effective and safe method to modulate
inflammation in metabolically-critical tissues and thus reduce insulin resistance and its
related complications.
The objectives of the study are to (1) determine whether salsalate therapy improves insulin
resistance in subjects with IGT and changes in glucose area under the curve following a
standard oral glucose tolerance test (OGTT); (2) determine whether salsalate therapy reduces
a) plasma levels of a variety of well established inflammatory proteins and b) mononuclear
cell inflammatory activity to provide evidence of reduced systemic and tissue inflammation,
respectively; and (3)also determine whether salsalate therapy improves parameters of
cardiovascular disease risk, including features of metabolic syndrome (fasting glucose,
triglycerides, HDL, and blood pressure) as well as endothelial dysfunction.