IBD is a chronic disease with two major types of Crohn's Disease (CD) and Ulcerative Colitis
(UC). Nowadays, synthetic drugs and monoclonal antibodies are the most common types of drugs
used for IBD management. However, due to their side effects and the high relapse rate, many
researchers are looking for plant-derived products to manage the disease. Saffron, Crocus
sativus L., is widely used as spice and medicine with anti-obesity, anticonvulsant,
anti-hyperlipidemic, anti-tumor, antioxidant, and anti-inflammatory properties. Besides,
there is evidence of the favorable effects of saffron on the gut microbiome. The main aim of
this proposal is to evaluate the effect of saffron as a complementary supplement or add-on
therapy in combination with current therapeutic agents in patients with mild and moderate UC.