Safety of Paracetamol as Antipyretic in Treatment of Dengue Infection in Adults

• Status: Completed
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether regular dosage of paracetamol causes transaminitis (hepatitis) and evaluate its potency in the treatment of dengue infection.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Phramongkutklao College of Medicine and Hospital
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Patient age >18 years

• Dengue infection diagnosed by NS1 antigen, Dengue immunoglobulin M antibody, or polymerase chain reaction

• Admitted to the hospital

• Written informed consent from patient or attending relative able to and willing to give informed consent

Exclusion Criteria:

• Other possible cause of fever other than dengue infection

• Pregnancy

• Unable to take medication

• Aminotransferase level above 3 times upper normal limit

• Allergy to paracetamol or tramadol

• Paracetamol indicated for condition other than dengue infection

• Critically ill patient who need ICU or invasive ventilation support

• History of cirrhosis

• Unable to comunicate